| Gene Symbol | ent-prot-c99e5a7f |
| Chromosome | 11p15 |
| Synaptic marker | Exclusively expressed in neuronal dendrites |
| Released with synaptic loss | Dendritic degeneration releases Ng into CSF |
| AD-specific | Elevations more pronounced in AD than other dementias |
| Complementary to tau | Ng reflects synaptic pathology, tau reflects neuronal loss |
| De Vos et al., 2015 | First large-scale validation of neurogranin |
| Kvartsberg et al., 2019 | Showed neurogranin predicts progression from MCI to AD |
| Milà-Alomà et al., 2020 | Neurogranin adds value to AT(N) classification |
| Thorsdottir et al., 2017 | Neurogranin changes in prodromal AD[@thors2017] |
| Sens et al., 2018 | Elevated neurogranin in autosomal dominant AD[@sens2018] |
| Elevated neurogranin | Consistent with AD-type synaptic pathology |
| Normal neurogranin | Less likely AD or early stage |
| Combined with Aβ/tau | Improves diagnostic accuracy |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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