| Gene Symbol | MRI |
| Parietal lobe | Superior and inferior parietal lobules |
| Frontal lobe | Precentral gyrus, superior frontal gyrus |
| Temporal lobe | Superior temporal gyrus (posterior) |
| Central region | Paracentral lobule |
| Putamen | Posterolateral putaminal atrophy (contralateral to symptoms) |
| Caudate nucleus | Head of caudate atrophy |
| Globus pallidus | Variable involvement |
| Midbrain | Moderate atrophy (less prominent than in PSP) |
| Superior cerebellar peduncle | Atrophy (characteristic) |
| Pons | Generally preserved |
| Hummingbird sign | Atrophy of the midbrain with preserved pons creates the appearance on sagittal images |
| Mickey mouse sign | Flattened midbrain on axial images |
| Morning glory sign | Concave dorsal midbrain |
| Tectal atrophy | Atrophy of the tectum |
| Cerebral aqueduct | Dilation |
| Associated Diseases | Alzheimer'S Disease, Amyotrophic Lateral Sclerosis, Huntington'S Disease, Neurodegenerative Disorders, Parkinson'S Disease |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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