| Gene Symbol | alzheimers |
| Aliases | alzheimers |
| Function | - Loss-of-function variants: Increase AD risk ~3-fold |
| Morphological transformation | From ramified surveillant to amoeboid activated state |
| Surface marker changes | Upregulation of CD68, Iba-1, TREM2 |
| Functional alterations | Changed phagocytic activity, cytokine secretion |
| Loss-of-function variants | Increase AD risk ~3-fold |
| sTREM2 | Soluble form released by activated microglia, detectable in CSF |
| CSF levels | Elevated in AD vs controls |
| A1 phenotype | Neurotoxic reactive astrocytes producing complement components |
| A2 phenotype | Potentially protective, producing neurotrophic factors |
| Marker changes | GFAP upregulation, YKL-40 expression |
| C1q | Initiates complement; localizes to amyloid plaques |
| C3 | Central component; elevated in AD brain and CSF |
| C5a | Pro-inflammatory anaphylatoxin; receptor blockage is neuroprotective in models |
| Association | Correlates with cognitive decline rate |
| Associated Diseases | ALZHEIMER |
| KG Connections | 85 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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