biomarker 2,854 words KG: PARKINSONS_DISEASE
Contents

5-Hydroxymethylcytosine (5-hmC) as a Biomarker for Parkinson's Disease

🔬 Protein Info
Gene SymbolPARKINSONS_DISEASE
AliasesParkinsons_disease, parkinsons-disease
Enrichment in gene bodies5-hmC is particularly enriched in the bodies of actively transcribed genes
Promoter regionsLower levels in promoters, but position-specific
EnhancersEnriched at active enhancer regions
神经元特异性Highest levels in neuronal tissue
Cell-type specificityVaries significantly between cell types
Associated DiseasesMULTIPLE_SCLEROSIS
Known Drugs/CompoundsASO
KG Connections16 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

Wikipedia

Related Hypotheses (22)

Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
← Prevpg 2/2

Related Analyses (14)

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Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · completed

Related Experiments (30)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

ALZHEIMERS_DISEASE associated_with PARKINSONS_DISEASE
PARKINSONS_DISEASE associated_with MULTIPLE_SCLEROSIS
ALPHA_SYNUCLEIN associated_with PARKINSONS_DISEASE
SNCA causes PARKINSONS_DISEASE
ASO treats PARKINSONS_DISEASE
PLK2_PROTEIN associated_with PARKINSONS_DISEASE
A53T causes PARKINSONS_DISEASE
C3 contributes_to PARKINSONS_DISEASE
NEURODEGENERATION contributes_to PARKINSONS_DISEASE
PARKINSONS_DISEASE causes DOPAMINE_NEURONS

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