| Gene Symbol | APE2 |
| Aliases | APE2PROTEIN |
| Chromosome | 6p25.2 |
| Protein Type | Gene |
| Function | is a DNA repair enzyme belonging to the DNA repair endonuclease family. |
| Primary Expression | all tissues, with high expression in: - Brain: neurons, astrocytes, microglia - Hea |
| Molecular Weight | 56 kDa |
| Amino Acids | 517 aa |
| GeneCards | APE2 |
| Human Protein Atlas | APE2 |
| N-terminal region | Contains mitochondrial targeting sequence |
| Catalytic domain | Exonuclease III-like endonuclease domain |
| HDEH motif | Conserved catalytic residues for endonuclease activity |
| Nuclear localization signal | Present in the C-terminal region |
| Base excision repair (BER) | Cleaves apurinic/apyrimidinic (AP) sites |
| Associated Diseases | cancer |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!