| Gene Symbol | ent-gene-a3471e41 |
| Chromosome | 5q22.2 |
| Function | of 2,843 amino acids that functions as a key negative regulator of the canonical Wnt/beta-catenin signaling pathway |
| Oligomerization domain (N-terminus) | Allows APC to form homodimers and heterodimers, essential for its scaffold function. |
| Armadillo repeats | Mediate interactions with beta-catenin, B-catenin, and other proteins containing armadillo repeat domains. |
| 15-amino acid repeats | Bind to beta-catenin with varying affinities. The SAMP repeats mediate beta-catenin degradation. |
| Basic domain | Binds to microtubules and regulates cytoskeletal dynamics. |
| C-terminal domain | Contains a EB1 binding site and PDZ domain for additional protein interactions. |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!