| Gene Symbol | APP |
| Aliases | AMYLOIDBETAPROTEIN |
| Chromosome | 21 |
| Protein Family | Amyloid precursor protein family |
| Function | is a 40-42 amino acid peptide that plays a central role in the pathogenesis of Alzheimer's disease (AD) and related amyloidopathies[@hardy2002]. |
| Primary Expression | Extracellular, membrane-associated |
| Subcellular Localization | </strong></td><td>Extracellular, neuronal membrane, endosomes</td></tr> |
| UniProt ID | P05067 |
| GeneCards | APP |
| Human Protein Atlas | APP |
| Aβ40 | Most abundant isoform (~80-90%) |
| Aβ42 | More hydrophobic, more aggregative (~5-10%) |
| Aβ43 | Highly aggregation-prone, most toxic |
| N-terminal | Contains epitopes for antibody therapeutics |
| C-terminal | Hydrophobic region drives aggregation |
| Associated Diseases | Alzheimer's Disease, Cerebral Amyloid Angiopathy |
| Databases | GeneCardsNCBI GeneHPASTRING |
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