| h-afb4b745b7 | Drp1-S616 Phosphorylation Fission Priming Enables t-Bid-Driven MPTP Amplificatio | 0.69 | 0.68 | DRP1 (DNM1L), BID | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062141-739c7f1c |
| h-6a065252 | Ocular Immune Privilege Extension | 0.69 | 0.20 | FOXP3/TGFB1 | debated | 2026-04-02 | sda-2026-04-01-gap-012 |
| h-fdb07848 | Sphingomyelin Synthase Activators for Raft Remodeling | 0.69 | 0.70 | SGMS1/SGMS2 | promoted | 2026-04-02 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-bbe4540f | cGAS-STING Senescence Circuit Disruption | 0.69 | 0.80 | CGAS, STING1 | promoted | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-725c62e9 | Extracellular Matrix Stiffness Modulation | 0.69 | 0.50 | PIEZO1 | debated | 2026-04-02 | sda-2026-04-01-gap-009 |
| h-28f5f4a34b | Complement C1q/C3 Inhibition to Prevent Synaptodendritis in Alzheimer's Disease | 0.69 | 0.78 | C1Q/C3 | proposed | 2026-04-29 | SDA-2026-04-28-gap-test-20260425-224949 |
| hyp-lyso-snca-f7d4ff | SNCA Aggregation Hijacks the Endosomal Sorting Complex Required for Transport (E | 0.69 | 0.72 | SNCA | active | 2026-04-28 | |
| h-fa83846f7d | Microglia and complement sustain post-Aβ neurodegeneration after tau missorting | 0.69 | 0.76 | C1QA,C1QB,C1QC,C3,ITGAM,TREM2,TYROBP | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-98a600b3ed |
| h-556fe28ea9 | Astrocyte Reactivity Heterogeneity with APOE4-Dependent Vulnerability | 0.69 | 0.65 | APOE | proposed | 2026-04-22 | SDA-2026-04-02-gap-seaad-debate-v4 |
| h-4814bca81e | Astrocyte-Neuron Metabolic Coupling Failure Precedes Neurodegeneration in FTD-GR | 0.69 | 0.71 | GRN, SLC16A3 (MCT4) | proposed | 2026-04-22 | SDA-2026-04-02-gap-2026-04-01-gap-006 |
| h-c7f5c90ab1 | TREM2-Dependent Microglial State Transition as Therapeutic Window in Alzheimer's | 0.69 | 0.78 | TREM2, SYK signaling pathway | proposed | 2026-04-22 | SDA-2026-04-02-gap-2026-04-01-gap-006 |
| h-a17f8f1de6 | TREM2 Agonism to Rescue APOE4-Induced Microglial Dysfunction | 0.69 | 0.70 | TREM2 | proposed | 2026-04-22 | SDA-2026-04-02-gap-apoe4-targeting |
| h-ae63a5a13c | H5: BET Bromodomain Readers Sense Aberrant Chromatin and Drive Neuroinflammatory | 0.69 | 0.75 | BRD4, BET bromodomains (BRD2/3/4) | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-120802 |
| h-9a862b0e02 | TFEB-Dependent Lysosome Biogenesis | 0.69 | 0.68 | TFEB/TFE3 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-a6cc7467 |
| h-f3751a9ee4 | Time-Limited AQP4 Inhibition for Acute Cytotoxic Edema Followed by Therapeutic R | 0.69 | 0.68 | AQP4 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2 |
| h-ebefda890e | Loss of AQP4 Polarization Impairs Glymphatic Perivascular Influx, Causing Metabo | 0.69 | 0.78 | AQP4 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-ce0abc1e |
| h-2a9928e512 | Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex pr | 0.69 | 0.66 | RAB27A | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062052-946439a8 |
| h-12599989 | Ganglioside Rebalancing Therapy | 0.69 | 0.65 | ST3GAL2/ST8SIA1 | proposed | 2026-04-02 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-b490c14bf6 | CSF Soluble TREM2 Fragment Ratio as Priming State Indicator | 0.69 | 0.58 | TREM2/ADAM10/17 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-69461336 | Endothelial NRF2 Activation as a Master Switch for Post-CA BBB Protection | 0.69 | 0.49 | NRF2 (NFE2L2) in brain microvascular endothelial cells | promoted | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-174000-6451afef |
| h-d2df6eaf | Reelin-Mediated Cytoskeletal Stabilization Protocol | 0.69 | 0.50 | RELN | debated | 2026-04-02 | sda-2026-04-01-gap-004 |
| h-eea667a9 | Cross-Seeding Prevention Strategy | 0.69 | 0.68 | TARDBP | debated | 2026-04-02 | sda-2026-04-01-gap-v2-68d9c9c1 |
| h-6b84d8e2 | Hypocretin-Neurogenesis Coupling Therapy | 0.69 | 0.30 | HCRT | debated | 2026-04-02 | sda-2026-04-01-gap-v2-18cf98ca |
| h-b295a9dd | Lysosomal Positioning Dynamics Modulation | 0.69 | 0.58 | LAMP1 | debated | 2026-04-02 | sda-2026-04-01-gap-011 |
| h-a54ec316 | Wnt/β-catenin Pathway Restoration | 0.69 | 0.72 | CTNNB1 | proposed | 2026-04-16 | SDA-2026-04-16-gap-bbb-tjp-20260416041707 |
| h-044ee057 | TREM2 Conformational Stabilizers for Synaptic Discrimination | 0.69 | 0.50 | TREM2 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-691b42f1 |
| h-SDA-2026-04-26-gap | Plasma D-Dimer Elevation Reflects Fibrinogen Leakage and Secondary Fibrinolysis | 0.69 | 0.44 | FGA, FGB, FGG, D-dimer | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-002803 |
| h-SDA-2026-04-26-gap | Blood Astrocyte-Derived Exosomal AQP4 Mislocalization Predicts Early Glymphatic | 0.69 | 0.44 | AQP4 | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-002803 |
| h-6ed7b5c8 | TREM2-APOE Axis Manipulation via APOE Lipidation for DAM Recruitment | 0.69 | 0.78 | TREM2-APOE | proposed | 2026-04-26 | SDA-2026-04-17-gap-microglial-subtypes-pharmaco-202604170000 |
| h-31980740 | GLUT1-Mediated Glucose Flux Coefficient as Neuroprotection Indicator | 0.68 | 0.60 | SLC2A1 | proposed | 2026-04-17 | SDA-2026-04-04-gap-debate-20260403-222618-c698b06a |
| h-73e4340b | Pericyte Contractility Reset via Selective PDGFR-β Agonism | 0.68 | 0.45 | PDGFRB | debated | 2026-04-02 | sda-2026-04-01-gap-v2-ee5a5023 |
| h-37d2482d | hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for | 0.68 | 0.30 | hnRNPA2B1, lncRNA-0021 (RBP-bound state) | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-150509-76c40dac |
| h-21d655104e | Focused Ultrasound with Microbubble Contrast Agents | 0.68 | 0.70 | IGFBPL1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf |
| h-analogy-aadfdd67 | FUS Phase Separation Dominance in FTD-TDP: Aberrant Condensate Hijacking of RNA | 0.68 | 0.65 | FUS | active | 2026-04-28 | |
| h-analogy-8b267076 | ISR/eIF2α~P Overflow Represses Synaptic Protein Synthesis Downstream of Tau/Aβ P | 0.68 | 0.65 | EIF2AK3 (PERK) | active | 2026-04-28 | |
| h-2698e999 | Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During Develop | 0.68 | 0.82 | SYNGAP1 | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-084510-fbfafe2c |
| h-2ca830cd | STMN2 Restoration as a Prerequisite for Axon Growth After TDP-43 Clearance | 0.68 | 0.78 | STMN2 | promoted | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917 |
| h-2651ca91 | Multi-Target Synergy via Presynaptic Vesicle Hub Convergence | 0.68 | 0.42 | TH, VMAT2, DAT, GCH1, BDNF, SNCA (presynaptic hub) | proposed | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-145531-5c4e7b59 |
| h-541d61c3 | Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles | 0.68 | 0.80 | APOE4 | promoted | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222543-20260402 |
| h-63b7bacd | Context-Dependent CRISPR Activation in Specific Neuronal Subtypes | 0.68 | 0.60 | Cell-type-specific essential genes | proposed | 2026-04-03 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-7eaed928c5 | TREM2 Microglial Activation Rescues Amyloid Clearance in AD | 0.68 | 0.82 | TREM2 | debated | 2026-04-26 | test-hypothesis-fixtures-v1 |
| h-1073c2422d | Differential Ubiquitin Chain Topology Creates 'Invisible' Surface on Pathologica | 0.68 | 0.65 | TRIM21, G3BP1, OTUD1/OTUD7B | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041423-3a6aa4ab |
| h-ca454967 | HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism | 0.68 | 0.68 | HDAC6, HSP90AA1 | proposed | 2026-04-13 | SDA-2026-04-12-gap-debate-20260410-113021-6fbc6da4 |
| 44b404ab-eabb-45a2-a | CCL2-CCR2 Driven Macrophage Infiltration Selectively Strips Fast-Fatigable NMJs | 0.68 | 0.42 | CCL2 | open | 2026-04-28 | f7f8019f-08f6-428b-adff-85e8ea202b60 |
| h-82100428d0 | mTORC1 Reactivation as Autophagy-Senescence Divergence Point Marker | 0.68 | 0.62 | MTOR, RPTOR, RPS6KB1, TSC1, TSC2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062101-724971bc |
| h-3e7d4f97 | Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mismatch Repair Modula | 0.68 | 0.65 | MSH3, PMS1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-a015e80e | Flotillin-1 Stabilization Compounds | 0.68 | 0.50 | FLOT1 | proposed | 2026-04-02 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-be9bab57 | PGE2–EP2–cAMP–PKA Axis Displaces Pathological Microglial Memory Traces | 0.68 | 0.62 | PTGER2 (EP2) → ADCY → cAMP → PRKA (PKA) → SIRT1 | proposed | 2026-04-26 | SDA-2026-04-08-gap-debate-20260406-062033-ad87c3fb |
| h-d7924e2bc6 | Autophagy-Lysosomal Degradation of IBA1 in Stressed Microglia | 0.68 | 0.62 | LC3/P62/SQSTM1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| h-420db533 | CRISPR-Mediated Mitochondrial Genome Editing for Complex I Dysfunction | 0.68 | 0.35 | MT-ND1, MT-ND4, MT-ND6 | proposed | 2026-04-04 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |