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Hypotheses

2,369 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-7ed5dae4TDP-43 Pathology Creates a Distinct Epigenetic Clock "Signature Divergence" Dete0.390.17TDP, LATE, AD, RNA, SEAactive2026-04-26SDA-2026-04-25-gap-epi-clock-biomarker-20260425-222549
h-e27562cbb4A-to-I RNA editing modulates the lncRNA-0021 binding site and tunes mmu-miR-63610.390.29ADAR1/ADAR2proposed2026-04-26SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate
h-var-c995a1e28aTREM2-Mediated Microglial Regulation of Oligodendrocyte Precursor Cell Maturatio0.380.34TREM2proposed2026-04-27SDA-2026-04-16-frontier-connectomics-84acb35a
h-24f6280dApolipoprotein E4-Mediated Metabolic Dysfunction Correction via Liver X Receptor0.380.50NR1H2 (LXRβ), APOEproposed2026-04-26SDA-2026-04-16-frontier-metabolomics-f03b09d9
h-7bb47d7aBacterial Enzyme-Mediated Dopamine Precursor Synthesis0.380.20TH, AADCarchived2026-04-02SDA-2026-04-01-gap-20260401-225155
h-aging-h6-cars-riskComposite Aging Risk Score (CARS) identifies hippocampus as the primary AD vulne0.380.76GFAPproposed2026-04-27SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-var-e09a2c99ffAstrocyte-Mediated Synaptic Tagging via CREB-S100B-RAGE Signaling0.380.26CREB1, S100B, AGER (RAGE)proposed2026-04-27SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9
h-var-6eb97ce157CREB-Mediated Differential CD55/CD46 Expression Creates Activity-Dependent Compl0.380.33CD55, CD46, CREB1proposed2026-04-27SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9
h-var-838f64eb52Complement Regulator CD55/CD46 Expression Modulates Microglial Engulfment During0.380.33CD55 (DAF), CD46 (MCP)proposed2026-04-27SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9
h-var-abc42270c3Activity-Dependent Synaptic Tagging via CREB-IGF1-IGF1R Signaling0.380.26CREB1, IGF1, IGF1Rproposed2026-04-27SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9
h-var-dbca541049CREB-Mediated Differential CD55/CD46 Expression Creates Activity-Dependent Compl0.380.33CREB1, CD55, CD46proposed2026-04-27SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9
h-var-9d4a43c4efAstrocytic Complement Regulator Release Modulates Synaptic Vulnerability (CD55/C0.380.33CD55 (DAF), CD46 (MCP)proposed2026-04-27SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9
h-var-071a199828TFEB Activation to Restore Lysosomal Function in Parkinson's Disease Alpha-Synuc0.380.26TFEBproposed2026-04-27SDA-2026-04-16-frontier-proteomics-1c3dba72
h-var-c622bde475TFEB Family-Wide Activation to Restore Lysosomal Networks in Early Alzheimer's S0.380.26TFEB/TFE3/TFE4 familyproposed2026-04-27SDA-2026-04-16-frontier-proteomics-1c3dba72
h-var-cddf0dc2a9TFEB Activation to Restore Lysosomal Biogenesis in Parkinson's Disease Dopaminer0.380.26TFEBproposed2026-04-27SDA-2026-04-16-frontier-proteomics-1c3dba72
h-var-d7dd33d5a3TFEB-mediated Autophagy Enhancement to Clear Protein Aggregates in Neurodegenera0.380.26TFEBproposed2026-04-27SDA-2026-04-16-frontier-proteomics-1c3dba72
h-var-5bc88e4dd8TFEB Family Multi-Target Activation for Synaptic Lysosomal Restoration in Alzhei0.380.26TFEB/TFE3/TFE4proposed2026-04-27SDA-2026-04-16-frontier-proteomics-1c3dba72
h-var-f988ec2954TFEB-Mediated Autophagosome-Lysosome Fusion Enhancement in Aged Neuronal Synapse0.380.26TFEBproposed2026-04-27SDA-2026-04-16-frontier-proteomics-1c3dba72
h-var-6ef1f43d79Chaperone-Autophagy Coupling Prevents Aggregate Persistence by Directing Seeds t0.380.34STUB1 (CHIP), autophagy pathway components (LC3, p62/SQSTM1)proposed2026-04-27SDA-2026-04-06-gap-debate-20260406-062052-28cbc764
h-var-ccdfa817f0Kinetic Threshold Model of Chaperone-CHIP Coupling: ATP Cycle Velocity Determine0.380.33STUB1proposed2026-04-27SDA-2026-04-06-gap-debate-20260406-062052-28cbc764
h-var-595760cb30Autophagy-Lysosomal Clearance Capacity Determines Therapeutic Window—Substrate C0.380.33LC3-II/p62 cargo recognition complexproposed2026-04-27SDA-2026-04-06-gap-debate-20260406-062052-28cbc764
h-var-139df78e35CHIP-mediated K63-linked ubiquitination promotes autophagosomal sequestration of0.380.34STUB1 (CHIP), HSPA8, SQSTM1, UBE2N, BECN1, ATG7proposed2026-04-27SDA-2026-04-10-gap-debate-20260410-075012-32bac138
h-var-09485f89f9CHIP-mediated K63-linked ubiquitination redirects oligomeric pathologic conforme0.380.34STUB1 (CHIP), HSPA8, VCP, SQSTM1, UBE2Nproposed2026-04-27SDA-2026-04-10-gap-debate-20260410-075012-32bac138
h-var-ef13aea74fExposed amyloidogenic segments trigger CHIP-mediated oligomer-selective ubiquiti0.380.35STUB1proposed2026-04-27SDA-2026-04-10-gap-debate-20260410-075012-32bac138
h-var-5d67613102HSP70 recognition of exposed β-sheet segments triggers CHIP-mediated selective d0.380.35STUB1proposed2026-04-27SDA-2026-04-10-gap-debate-20260410-075012-32bac138
h-var-0648992d66Amyloidogenic segments undergo conformational templating by HSP90-HSP70 heteroco0.380.35HSP90AA1, HSPA8, HSPA1A, DNAJB6, DNAJB2, STIP1proposed2026-04-27SDA-2026-04-10-gap-debate-20260410-075012-32bac138
h-var-c027b2a8eeHSP90-CDC37 complex recognizes exposed hydrophobic clusters as amyloidogenic dan0.380.35HSP90AA1, HSP90AB1, CDC37proposed2026-04-27SDA-2026-04-10-gap-debate-20260410-075012-32bac138
h-var-9d9dc08d4dGluN2B-Mediated Microglial Activation and Tau Phagocytosis0.380.59GRIN2Bproposed2026-04-27SDA-2026-04-03-26abc5e5f9f2
h-var-f08f96e530TREM2-Regulated Astrocytic Calcium Dynamics Control Glymphatic Tau Clearance0.380.62TREM2proposed2026-04-27SDA-2026-04-26-trem2-showcase
h-var-05d273b7f3RAGE-Mediated Transcytotic Pump Enhancement Strategy0.380.53LDLRproposed2026-04-27SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-var-fcc307041aTREM2-Mediated Microglial Dysfunction Impairs Synaptic Tau Propagation Blockade0.380.62TREM2proposed2026-04-27SDA-2026-04-26-trem2-showcase
h-var-358e882d05LDLR-Primed LRP1 Transcytosis with Endosomal Liberation Strategy0.380.53LDLRproposed2026-04-27SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-var-bb6677aa73LDLR-Mediated Reverse Cholesterol Transport Modulation for CNS Drug Delivery0.380.53LDLRproposed2026-04-27SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-var-76490d8b19LDLR-Mediated Neuroinflammation Modulation Strategy0.380.53LDLRproposed2026-04-27SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-var-51f61f705dLDLR-Primed LRP1 Transcytosis with pH-Activated Endosomal Escape0.380.53LDLRproposed2026-04-27SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-var-a4a4a4b781LDLR-Mediated Lipid Carrier Neurotherapeutic Delivery0.380.53LDLRproposed2026-04-27SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-var-978902877fcGAS Inhibitors for ALS Therapeutics: Targeting Upstream mtDNA Recognition0.380.33MB21D1 (cGAS)proposed2026-04-27SDA-2026-04-07-gap-pubmed-20260406-062141-fc60e018
h-var-09a731430dMitophagy Enhancement Blocks STING-Mediated Neuroinflammation in ALS0.380.55PINK1promoted2026-04-27SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-var-12da54be2cPINK1/PARK2 Mitophagy Enhancement for Microglial Polarization0.380.55PINK1promoted2026-04-27SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-var-fb974d4b65TREM2-Mediated Oligodendrocyte Metabolic Support in White Matter Neurodegenerati0.380.71TREM2proposed2026-04-27SDA-2026-04-26-trem2-showcase
h-var-f1f624c111TREM2-Mediated Senescent Microglial Reprogramming of Astrocyte Networks0.380.71TREM2promoted2026-04-27SDA-BIOMNI-SPATIAL_-c2b61633
h-var-47bbbf5711TREM2-Dependent Astrocyte-Microglia Cross-talk in Neuroinflammation0.380.71TREM2promoted2026-04-27SDA-BIOMNI-SPATIAL_-c2b61633
h-var-288308c7dcTheta-Alpha Oscillation Entrainment Enhances lncRNA-9969-Mediated Mitochondrial 0.380.34SST, CREB1, lncRNA-9969, PGC1A, TFAMproposed2026-04-27SDA-2026-04-16-gap-pubmed-20260410-150509-76c40dac
h-var-08fd0f5a54CREB1-Induced lncRNA-9969 Selectively Binds miR-6361 Through Dual Seed-Structure0.380.34lncRNA-9969proposed2026-04-27SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate
h-var-39780e4efaCompetitive endogenous RNA network modulates mmu-miR-6361 availability through l0.380.34lncRNA-0021proposed2026-04-27SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate
h-var-4bd74ce5ceEnhancement of Astrocytic Ketone Body Production via HMGCS2 Overexpression0.380.26HMGCS2proposed2026-04-27SDA-2026-04-16-frontier-metabolomics-f03b09d9
h-var-ffacbbd9f1NAD+-Dependent Upregulation of MCT1 Expression to Restore Neuronal Ketone Metabo0.380.26SLC16A1 (MCT1)proposed2026-04-27SDA-2026-04-16-frontier-metabolomics-f03b09d9
h-var-595ee613e2LXRα-Selective Agonism to Enhance Hepatic APOE Secretion and Peripheral Choleste0.380.34LXRα (NR1H3)proposed2026-04-27SDA-2026-04-16-frontier-lipidomics-dcdbc360
h-var-de3e3c7494CD38 Inhibition to Preserve NAD+ Pools and Prevent PARP1-Mediated Metabolic Dysf0.380.26CD38, PARP1, SIRT1/3proposed2026-04-27SDA-2026-04-16-frontier-metabolomics-f03b09d9
h-var-12f509effbLXRβ-Selective Agonism Enhances CYP2J2-Mediated DHA Epoxide Generation to Restor0.380.34NR1H2 (LXRβ)proposed2026-04-27SDA-2026-04-16-frontier-lipidomics-dcdbc360
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