SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
← Pipeline / 🧬

Hypotheses

2,369 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-64c36c7cNRF2-KEAP1 Pathway Activation to Coordinate Multi-Layer Antioxidant Defense0.650.65NRF2 (NFE2L2), KEAP1proposed2026-04-17SDA-2026-04-16-gap-ferroptosis-als-d2fb6bf796ed
h-58e655eeAPOE-Mediated Synaptic Lipid Raft Stabilization0.650.50SPTLC1proposed2026-04-03sda-2026-04-01-gap-auto-fd6b1635d9
h-b7fb180808Autophagic Flux Enhancement Synergizes With Chaperones to Clear High-Molecular-W0.650.70TFEB, LAMP2A, SQSTM1proposed2026-04-22SDA-2026-04-06-gap-debate-20260406-062052-28cbc764
h-c35493aaGlial Glycocalyx Remodeling Therapy0.650.30HSPG2debated2026-04-02sda-2026-04-01-gap-005
h-4ae1454184CX3CR1 Promoter Methylation Disrupts Neuron-Microglia Cross-Talk0.650.72CX3CR1proposed2026-04-21SDA-2026-04-07-gap-debate-20260406-062045-56983337
h-b262f4c9d8p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle Cargo for Coordinat0.650.68SQSTM1/p62 (SQSTM1), ULK1/FIP200proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7
h-var-9d0c0787a5APOE-TREM2 Ligand Availability Dysfunction in Neurodegeneration0.650.80APOEpromoted2026-04-17SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-var-71ac892791Age-Dependent TREM2 Signaling Disrupts Astrocyte-Microglia Communication Leading0.650.80TREM2proposed2026-04-17SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-var-33f643b43aTREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling in White Matter Neur0.650.80TREM2proposed2026-04-17SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
SDA-2026-04-16-hyp-aApoptosis-Senescence Decision Point Intervention0.650.48TP53,BAX,BAK1,CASP3proposed2026-04-16SDA-2026-04-04-gap-senescent-clearance-neuro
h-88e23c4aIL-10-Producing B10 Cells Establish AQP4-Specific Peripheral Tolerance Through M0.650.58IL10, CSF1R, CD40promoted2026-04-14SDA-2026-04-13-gap-pubmed-20260410-142329-c1db787b
h-509dad7981ALS-Linked OPTN/TBK1 Mutations Impair Phosphorylation Cascade Required for Patho0.650.64OPTN, TBK1proposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041423-3a6aa4ab
h-ef5f2ec0CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic Target0.650.72CLU-APOE-TREM2 axis (LXR/RXR pathway)promoted2026-04-15SDA-2026-04-14-gap-pubmed-20260410-193701-11582758
h-782e55f6DNMT1-Targeting Antisense Oligonucleotide Reset0.650.30DNMT1debated2026-04-02sda-2026-04-01-gap-v2-bc5f270e
h-d40d2659HCN1-Mediated Resonance Frequency Stabilization Therapy0.650.40HCN1debated2026-04-02sda-2026-04-01-gap-004
h-13bbfdc5Mitochondrial SPM Synthesis Platform Engineering0.650.20ALOX5debated2026-04-02sda-2026-04-01-gap-014
h-e5f1182bEpigenetic Reprogramming of Microglial Memory0.650.60DNMT3A, HDAC1/2debated2026-04-04SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-e37e76c0S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF-κB/Claudin-5 Axis0.650.18S100Bproposed2026-04-26SDA-2026-04-26-gap-bbb-permeability-biomarker-20260426
h-a1d97415Inflammatory State-Dependent Ketone Timing0.650.40IRAKMproposed2026-04-17SDA-2026-04-03-gap-debate-20260403-222618-2709aad9
h-57862f8aGrid Cell-Specific Metabolic Reprogramming via IDH2 Enhancement0.650.20IDH2debated2026-04-02sda-2026-04-01-gap-004
h-3e6ca50b2fActivity-Dependent Synaptic Tagging via CREB-BDNF-TrkB Signaling0.650.52CREB1, BDNF, NTRK2 (TrkB)proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9
h-e3506e5aSynthetic Biology Rewiring via Orthogonal Receptors0.650.50CNOdebated2026-04-02sda-2026-04-01-gap-009
h-SDA-2026-04-26-gapEndothelial miR-181c-5p Upregulation Drives Claudin-5 Repression and Paracellula0.650.43CLDN5 (Claudin-5) - regulated by miR-181c-5pproposed2026-04-26SDA-2026-04-26-gap-debate-20260426-011448-7c85f5dc
h-SDA-2026-04-26-gapDominant-Negative Spliceosome Titration0.650.43U2AF2, SF3B1, PRPF8; splicing snRNPsproposed2026-04-26SDA-2026-04-26-gap-pubmed-20260412-094853-199f4f1b
h-a3580b22Retromer-dependent retrograde endosomal signaling compartmentalization as biomar0.650.62VPS35, VPS26, VPS29 (retromer complex); TrkB/NTRK2 (cargo reproposed2026-04-26SDA-2026-04-10-gap-debate-20260410-075000-7396040a
h-e6437136Ephrin-B2/EphB4 Axis Manipulation0.640.20EPHB4debated2026-04-02sda-2026-04-01-gap-005
h-e003a35eOligodendrocyte Remyelination Enhancement0.640.60TREM2proposed2026-04-04SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-e714137dd7MCU Calcium Overload via MFN2/GRP75/VDAC1 MAM Dysfunction0.640.62MFN2, GRP75 (HSPA9), MCU (MICU1/2)proposed2026-04-21SDA-2026-04-08-gap-pubmed-20260406-062141-739c7f1c
h-699c0d72Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotective Strategy0.640.75promoted2026-04-15SDA-2026-04-15-gap-pubmed-20260411-075356-20920528
h-cb1d193197Microglial Metabolic Trained Immunity via mTOR-HIF1α Axis0.640.70MTOR/HIF1αproposed2026-04-21SDA-2026-04-07-gap-debate-20260406-062045-56983337
h-8efcb4cfH1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to A0.640.52TREM2proposed2026-04-14SDA-2026-04-26-trem2-showcase
h-245c3e93White Matter Immune Checkpoint Restoration0.640.30CXCL10proposed2026-04-04SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-8dc75e4072HDAC2 Phospho-Lock Window for Synaptic Gene Silencing0.640.72HDAC2 (phospho-S421)proposed2026-04-21SDA-2026-04-07-gap-debate-20260406-062039-7ef9980b
h-67d4435cb5Epigenetic Silencing of AIF1 Gene Locus by Chronic Inflammation0.640.55DNMT1/DNMT3Aproposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb
h-b34120a1Cell-Type Specific Metabolic Reprogramming0.640.30PPARAproposed2026-04-14SDA-2026-04-03-gap-seaad-v4-20260402065846
h-ed23619cHDAC6 Selective Inhibition to Restore Acetylation Balance and Microtubule Stabil0.640.68HDAC6promoted2026-04-13SDA-2026-04-13-gap-debate-20260412-094556-86f36bb3
h-var-ac50d1e3d1SASP-Driven Microglial Metabolic Reprogramming in Synaptic Phagocytosis0.640.65HK2/PFKFB3proposed2026-04-07sda-2026-04-01-gap-013
h-7a5be68a9eJ-protein co-chaperone repertoire enables selective recognition of pathogenic co0.640.58DNAJB6, DNAJB2, HSPA8, HSPA1Aproposed2026-04-21SDA-2026-04-10-gap-debate-20260410-075012-32bac138
h-var-7e118a66d8TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration0.640.72TREM2archived2026-04-07SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-var-a8c6c6ea92TREM2-Mediated Mitochondrial Dysfunction in Neurodegeneration0.640.80TREM2promoted2026-04-20SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-var-56a6156e67TREM2-Driven Senescence Biomarker Index for Predicting Neurodegeneration Risk0.640.78TREM2promoted2026-04-20SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-f7da6372Mitochondrial ATP/ADP Carrier Activity as Bioenergetic Recovery Metric0.640.40SLC25A4proposed2026-04-17SDA-2026-04-04-gap-debate-20260403-222618-c698b06a
h-8b7727c1Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cross-Seeding0.640.40CSGAproposed2026-04-03SDA-2026-04-01-gap-20260401-225149
h-var-1dc420e7d8CYP46A1 Suppression for Tau-Mediated Neurodegeneration0.640.35CYP46A1proposed2026-04-07SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-7e846cebGlycine-Rich Domain Competitive Inhibition0.640.55TARDBPdebated2026-04-02sda-2026-04-01-gap-006
h-16ae38923dEndosomal-Retromer Trafficking Defect as a Shared Sorting Failure0.640.68VPS35, VPS26, SORL1, SNX27proposed2026-04-28SDA-2026-04-28-cross-disease-synthesis
h-metrep-a7cf1c8bed7mTORC1 Displacement from Lysosomal Membrane Enables TFEB Nuclear Translocation a0.640.75MTOR,RPTOR,TFEB,RragA,RragC,GABARAPL1,LAMP1,CTSD,ULK1proposed2026-04-28
h-metrep-b3a540aad7eCaloric Restriction Mimetic Combination Therapy (Metformin + Resveratrol + Rapam0.640.75AMPK,PRKAA1,PRKAA2,SIRT1,MTOR,RPTOR,PPARGC1A,FOXO3,FOLH1proposed2026-04-28
h-377232dcc8LRRK2 G2019S Uncouples RAB29-Dependent Spatial Control from Kinase Activity (H7)0.640.62LRRK2,RAB29proposed2026-04-26SDA-2026-04-23-gap-debate-20260417-033119-54941818
h-SDA-2026-04-26-gapCirculating Endothelial Microvesicles Expressing Degraded Claudin-5 as Specific 0.640.52CLDN5 fragments on CD31+/CD144+ EMVsproposed2026-04-26SDA-2026-04-26-gap-debate-20260426-011448-7c85f5dc
1112131415
SciDEX — scidex.ai — Dashboard | Mission Control | Status | How it Works | GitHub