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Debates

864 items
IdQuestionQuality ScoreNum Hypotheses GeneratedNum RoundsStatusCreated AtAnalysis Id
sess_SDA-2026-04-25-Does C1q function differ based on subcellular localization or binding partner id0.6864completed2026-04-25SDA-2026-04-25-gapdebate-afba1a80bd
sess_SDA-2026-04-25-Do physiological concentrations of SCFAs (μM range) achieve therapeutic effects 0.6364completed2026-04-25SDA-2026-04-25-gapdebate-18cce7b525
sess_SDA-2026-04-25-Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas0.7454completed2026-04-25SDA-2026-04-25-gapdebate-9180363b7c
sess_SDA-2026-04-25-Does APOE4's reduced lipid-binding directly modulate SREBP2-SCAP complex retenti0.5864completed2026-04-25SDA-2026-04-25-gapdebate-f4c8357045
sess_aging-mouse-braHow does gene expression change across age groups (young/middle/old) in hippocam1.0034completed2026-04-24aging-mouse-brain-2026-04-02
pan_0b9f67e3is the amyloid cascade hypothesis still important0.5000completed2026-04-24
pan_5d0f52d1Is the amyloid hypothesis still tractable for AD?0.5000completed2026-04-24
sess_hyp_h-b2aeabb1_Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat0.7604completed2026-04-23SDA-2026-04-16-gap-bbb-tjp-20260416041707
sess_hyp_SDA-2026-04Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to 0.8104completed2026-04-23SDA-2026-04-04-gap-senescent-clearance-neuro
target_debate_t-2a37Should MAPT (None) be prioritized as a therapeutic target for neurodegeneration?0.5004completed2026-04-23
target_debate_targetShould PIEZO1ANDKCNK2 (PIEZO1ANDKCNK2) be prioritized as a therapeutic target fo0.5004completed2026-04-23
target_debate_targetShould CELL-TYPE-SPECIFICESSENTIALGENES (CELL-TYPE-SPECIFICESSENTIALGENES) be pr0.5004completed2026-04-23
target_debate_targetShould SIRT3 (NAD-dependent deacetylase sirtuin-3, mitochondrial) be prioritized0.5004completed2026-04-23
target_debate_targetShould AADC (Aromatic L-amino acid decarboxylase) be prioritized as a therapeuti0.5004completed2026-04-23
target_debate_targetShould CHRNA7 (CHRNA7 Protein) be prioritized as a therapeutic target for neurod0.5004completed2026-04-23
target_debate_targetShould GPR109A (Hydroxycarboxylic Acid Receptor 2 (HCAR2)) be prioritized as a t0.5004completed2026-04-23
target_debate_targetShould MAP6 (Microtubule-associated protein 6) be prioritized as a therapeutic t0.5004completed2026-04-23
target_debate_targetShould GFAP (Glial fibrillary acidic protein) be prioritized as a therapeutic ta0.5004completed2026-04-23
target_debate_targetShould ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2) be prioritiz0.5004completed2026-04-23
target_debate_targetShould MTOR (Mechanistic Target of Rapamycin) be prioritized as a therapeutic ta0.5004completed2026-04-23
target_debate_targetShould CSGA (CSGA Protein) be prioritized as a therapeutic target for neurodegen0.5004completed2026-04-23
target_debate_targetShould CNO (Cappuccino) be prioritized as a therapeutic target for neurodegenera0.5004completed2026-04-23
target_debate_targetShould CHMP4B (Charged multivesicular body protein 4B) be prioritized as a thera0.5004completed2026-04-23
target_debate_targetShould SLC16A2 (Monocarboxylate transporter 8) be prioritized as a therapeutic t0.5004completed2026-04-23
target_debate_targetShould CLDN1 (Claudin-1) be prioritized as a therapeutic target for neurodegener0.5004completed2026-04-23
target_debate_targetShould CLDN5 (Claudin-5) be prioritized as a therapeutic target for neurodegener0.5004completed2026-04-23
target_debate_targetShould ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1) be0.5004completed2026-04-23
target_debate_targetShould BRD4 (Bromodomain-containing protein 4) be prioritized as a therapeutic t0.5004completed2026-04-23
target_debate_targetShould LOXL1-4 (Lysyl oxidase-like 1-4) be prioritized as a therapeutic target f0.5004completed2026-04-23
target_debate_targetShould CAV1 (Caveolin-1) be prioritized as a therapeutic target for neurodegener0.5004completed2026-04-23
target_debate_targetShould FLOT1 (Flotillin 1) be prioritized as a therapeutic target for neurodegen0.5004completed2026-04-23
target_debate_targetShould AQP4 (Aquaporin-4) be prioritized as a therapeutic target for neurodegene0.5004completed2026-04-23
target_debate_targetShould SGMS1 (Sphingomyelin synthase 1) be prioritized as a therapeutic target f0.5004completed2026-04-23
target_debate_targetShould SIRT1 (NAD-dependent protein deacetylase sirtuin-1) be prioritized as a t0.5004completed2026-04-23
target_debate_targetShould GAP43 (Growth associated protein 43) be prioritized as a therapeutic targ0.5004completed2026-04-23
target_debate_targetShould FUT8 (Alpha-(1,6)-fucosyltransferase) be prioritized as a therapeutic tar0.5004completed2026-04-23
target_debate_targetShould MCU (Mitochondrial calcium uniporter) be prioritized as a therapeutic tar0.5004completed2026-04-23
target_debate_targetShould SGMS2 (Sphingomyelin synthase 2) be prioritized as a therapeutic target f0.5004completed2026-04-23
target_debate_targetShould RELN (Reelin) be prioritized as a therapeutic target for neurodegeneratio0.5004completed2026-04-23
target_debate_targetShould SNAP25 (Synaptosome associated protein 25) be prioritized as a therapeuti0.5004completed2026-04-23
target_debate_targetShould PLA2G6 (Phospholipase A2 group VI) be prioritized as a therapeutic target0.5004completed2026-04-22
target_debate_targetShould SETX (Senataxin) be prioritized as a therapeutic target for neurodegenera0.5004completed2026-04-22
target_debate_targetShould FOXP3 (Forkhead box protein P3) be prioritized as a therapeutic target fo0.5004completed2026-04-22
target_debate_targetShould CHR2 (Channelrhodopsin-2) be prioritized as a therapeutic target for neur0.5004completed2026-04-22
target_debate_targetShould SYNCRIP (Heterogeneous nuclear ribonucleoprotein Q) be prioritized as a t0.5004completed2026-04-22
target_debate_targetShould DGAT1 (Diacylglycerol O-Acyltransferase 1) be prioritized as a therapeuti0.5004completed2026-04-22
target_debate_targetShould HSPG2 (Heparan Sulfate Proteoglycan 2) be prioritized as a therapeutic ta0.5004completed2026-04-22
target_debate_targetShould PLIN2 (Perilipin 2) be prioritized as a therapeutic target for neurodegen0.5004completed2026-04-22
target_debate_targetShould ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1) be prioritiz0.5004completed2026-04-22
target_debate_targetShould PYCARD (Apoptosis-associated speck-like protein containing CARD) be prior0.5004completed2026-04-22
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