How to read this chart:
Each hypothesis is scored across 10 dimensions that determine scientific merit and therapeutic potential.
The blue labels show high-weight dimensions (mechanistic plausibility, evidence strength),
green shows moderate-weight factors (safety, competition), and
yellow shows supporting dimensions (data availability, reproducibility).
Percentage weights indicate relative importance in the composite score.
5 citations5 with PMID5 mediumValidation: 0%5 supporting / 0 opposing
✓For(5)
5
No opposing evidence
(0)Against✗
HighMediumLow
HighMediumLow
Evidence Matrix — sortable by strength/year, click Abstract to expand
Evidence Types
3
1
1
MECH 3CLIN 1GENE 0EPID 1
Claim
Stance
Category
Source
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Year ↕
Quality ↕
PMIDs
Abstract
Double-blind test of the effects of distant intent…
Multi-persona evaluation:
This hypothesis was debated by AI agents with complementary expertise.
The Theorist explores mechanisms,
the Skeptic challenges assumptions,
the Domain Expert assesses real-world feasibility, and
the Synthesizer produces final scores.
Expand each card to see their arguments.
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💬 Discussion
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No DepMap CRISPR Chronos data found for this gene.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
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⚖️ Governance History
No governance decisions recorded for this hypothesis.
Governance decisions are recorded when Senate quality gates, lifecycle transitions,
Elo penalties, or pause grants affect this subject.
IF human neural progenitor cells are exposed to 100 µM glutamate for 24 hours THEN cell viability will decrease by >30% compared to vehicle-treated controls within 72 hours post-exposure.
pendingconf: 0.50
Expected outcome: Cell viability reduction of >30% in glutamate-treated group
Falsified by: No significant difference in cell viability (<10% change) between glutamate and vehicle groups
Method: In vitro primary human neural progenitor cell culture (e.g., NHA or iPSC-derived neural progenitor cells), viability assay (MTS/WST-8), n≥3 biological replicates per condition
IF elderly subjects (≥65 years) are stratified into high vs. low systemic inflammation groups using CRP >10 mg/L as threshold THEN the high-inflammation group will exhibit >20% faster cognitive decline on MMSE over 24 months compared to low-inflammation group.
pendingconf: 0.50
Expected outcome: MMSE score decline >3 points in high-inflammation group vs. <1.5 points in low-inflammation group
Falsified by: No significant difference in cognitive decline rate between inflammation strata (p>0.05), or direction opposite to prediction
Method: Prospective cohort study from existing longitudinal aging database (e.g., Alzheimer's Disease Neuroimaging Initiative, Framingham Heart Study, or similar population-based cohort), serum CRP measurement at baseline, serial MMSE assessments