Temporal analysis of cell-type proportions revealed early reduction of Somatostatin-expressing neuronal subtypes, late decreases in supragranular intratelencephalic-projecting excitatory and Parvalbum

Cell_Biology Score: 0.500 Price: $0.50 Alzheimer's disease post_mortem_brain Status: extracted

What This Experiment Tests

Cell_Biology experiment designed to assess clinical efficacy targeting N/A in post_mortem_brain. Primary outcome: Temporal analysis of cell-type proportions revealed early reduction of Somatostatin-expressing neuro

Description

Cell type proportion analysis across disease progression pseudotime

TARGET GENE

N/A

MODEL SYSTEM

post_mortem_brain

ESTIMATED COST

TIMELINE

0 months

PATHWAY

N/A

SOURCE

pmid_37292694

PRIMARY OUTCOME

Temporal analysis of cell-type proportions revealed early reduction of Somatostatin-expressing neuronal subtypes, late decreases in supragranular intratelencephalic-projecting excitatory and Parvalbumin-expressing neurons, and increases in disease-associated microglial and astrocytic states.

Scoring Dimensions

Related Hypotheses (1)

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease0.827

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