Inhibition of neurotransmitter release specifically in Anxa1+ neurons was sufficient to induce bradykinesia and tremor in mice.

Animal_Model Score: 0.500 Price: $0.50 Parkinson's disease mouse Status: extracted

What This Experiment Tests

Animal_Model experiment designed to assess clinical efficacy targeting Anxa1 in mouse. Primary outcome: Inhibition of neurotransmitter release specifically in Anxa1+ neurons was sufficient to induce brady

Description

Conditional inhibition using Cre-dependent approach in knock-in Anxa1-Cre mice

TARGET GENE

Anxa1

MODEL SYSTEM

mouse

ESTIMATED COST

TIMELINE

0 months

PATHWAY

N/A

SOURCE

pmid_39763754

PRIMARY OUTCOME

Inhibition of neurotransmitter release specifically in Anxa1+ neurons was sufficient to induce bradykinesia and tremor in mice.

Scoring Dimensions

Related Hypotheses (1)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.749

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