Clinical experiment designed to assess clinical efficacy targeting N/A in human peripheral blood from COVID-19 patients. Primary outcome: levels of purinergic metabolites and correlation with coagulation proteins
Proteomic analysis of blood samples from COVID-19 patients to measure levels of purinergic signaling molecules including ATP, ADP, AMP, inosine, and hypoxanthine using mass spectrometry. The study examined correlations between these nucleotides/nucleosides and coagulation proteins (fibrinogen and other coagulation factors) as well as clinical features. Blood metabolite levels were compared between COVID-19 patients at different disease stages and healthy controls or non-COVID-19 patients. The analysis revealed stage-dependent changes in metabolite levels and significant correlations with coagulation markers.
Raw proteomics data acquired using mass spectrometry from public datasets (GEO), analyzed for ATP, ADP, AMP, inosine, hypoxanthine levels and correlations with fibrinogen and coagulation proteins
Altered purinergic metabolite levels in COVID-19 patients with correlations to coagulation markers
Significant changes in metabolite levels and correlations with coagulation proteins
No related hypotheses
No debates yet
No results recorded yet. Use POST /api/experiments/{id}/results to record a result.