Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucleotide variants in AD brains compared to age-matched controls.

Genetic_Association Score: 0.500 Price: $0.50 Alzheimer's disease in_vivo Status: extracted

What This Experiment Tests

Genetic_Association experiment designed to assess clinical efficacy targeting cancer driver genes; clonal hematopoiesis genes (CSF1R) in in_vivo. Primary outcome: Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of

Description

Three orthogonal methods used across three independent AD cohorts; bulk RNA sequencing approach for variant detection

TARGET GENE

cancer driver genes; clonal hematopoiesis genes (CSF1R)

MODEL SYSTEM

in_vivo

ESTIMATED COST

TIMELINE

0 months

PATHWAY

somatic mutation accumulation; clonal hematopoiesis

SOURCE

pmid_38260600

PRIMARY OUTCOME

Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucleotide variants in AD brains compared to age-matched controls.

Scoring Dimensions

Related Hypotheses (1)

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