Evidence regarding pain in VPS35 pathogenic variants is limited and insufficient.

Genetic_Association Score: 0.500 Price: $0.50 Parkinson's disease human Status: extracted

What This Experiment Tests

Genetic_Association experiment designed to assess clinical efficacy targeting VPS35 in human. Primary outcome: Evidence regarding pain in VPS35 pathogenic variants is limited and insufficient.

Description

Insufficient data from systematic review

TARGET GENE

VPS35

MODEL SYSTEM

human

ESTIMATED COST

TIMELINE

0 months

PATHWAY

null

SOURCE

pmid_38020640

PRIMARY OUTCOME

Evidence regarding pain in VPS35 pathogenic variants is limited and insufficient.

Scoring Dimensions

Related Hypotheses (3)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.749

VPS35 retromer activation prevents endosomal tau templating across all brain regions and disease sta0.740

VPS35 Retromer Dysfunction Creates a GCase Trafficking Bottleneck that Synergizes with GBA1 Mutation0.700

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