Exploratory experiment designed to discover new patterns targeting ABCA1 in human patients. Primary outcome: association between genetic polymorphisms and dementia risk
A case-control genetic association study investigating polymorphisms associated with dementia risk in patients with hyperlipidemia. The study genotyped 203 patients across three groups: 109 with both dementia and hyperlipidemia, 94 with hyperlipidemia only, and 101 controls for allele frequency analysis. Multiple polymorphisms were tested, with focus on those previously identified in literature as potentially useful for dementia risk assessment. The study included cognitive assessments using neuropsychological tests including the Montreal Cognitive Assessment (MoCA) scale. The primary finding was that ABCA1 rs2230806 polymorphism showed significant association with dementia, particularly Alzheimer's disease, with the GG genotype and G allele being more frequent in dementia patients.
Case-control study design with genotyping of multiple polymorphisms in three patient groups (dementia+hyperlipidemia, hyperlipidemia only, controls). Cognitive assessment using neuropsychological tests including MoCA scale. Statistical analysis comparing allele and genotype frequencies between groups.
Identification of polymorphisms that could serve as biomarkers for early dementia risk assessment in hyperlipidemic patients
Statistically significant differences in allele or genotype frequencies between dementia and control groups
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