Validation experiment designed to validate causal mechanisms targeting N/A in mice. Primary outcome: LPS levels in bacterial extracellular vesicles
Parallel to the human studies, bacterial extracellular vesicles were extracted from mouse fecal and blood samples to measure LPS content. This animal model component provided a controlled experimental system to validate findings from human samples and potentially investigate mechanisms of bEV transport and function in a laboratory setting where variables could be better controlled.
Extraction of bEVs from mouse feces and blood samples, measurement of LPS levels
Detectable LPS-containing bEVs in mouse samples
Successful isolation and quantification of LPS in mouse-derived bEVs
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