Human iPSC-derived AD model with optical electrophysiology demonstrated that mTOR inhibition ameliorates spheroid pathology, revealing reversible mechanisms of axonal pathology.

Cell_Biology Score: 0.500 Price: $0.50 Alzheimer's disease ipsc Status: extracted

What This Experiment Tests

Cell_Biology experiment designed to assess clinical efficacy targeting MTOR in ipsc. Primary outcome: Human iPSC-derived AD model with optical electrophysiology demonstrated that mTOR inhibition amelior

Description

iPSC-derived neurons with optical electrophysiology for functional studies

TARGET GENE

MTOR (Score: 0.419)

MODEL SYSTEM

ipsc

ESTIMATED COST

TIMELINE

0 months

PATHWAY

PI3K/AKT/mTOR

SOURCE

pmid_40065072

PRIMARY OUTCOME

Human iPSC-derived AD model with optical electrophysiology demonstrated that mTOR inhibition ameliorates spheroid pathology, revealing reversible mechanisms of axonal pathology.

Scoring Dimensions

Related Hypotheses (4)

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease0.827

APOE-Dependent Autophagy Restoration0.877

Chronic mTORC1-ULK1 signaling blocks autophagy initiation in irradiated pericytes0.578

Metabolic Checkpoint Reprogramming via TREM2-mTOR Axis0.455

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