GPR37 deficiency in oligodendrocytes prevented neurodegeneration in multiple PD models, reducing neuroinflammation, dopamine neuron degeneration, and behavioral deficits.

Animal_Model Score: 0.500 Price: $0.50 Parkinson's disease mus_musculus Status: extracted

What This Experiment Tests

Animal_Model experiment designed to assess clinical efficacy targeting GPR37 in mus_musculus. Primary outcome: GPR37 deficiency in oligodendrocytes prevented neurodegeneration in multiple PD models, reducing neu

Description

Genetic manipulation using GPR37-deficient oligodendrocytes tested across multiple PD animal models

TARGET GENE

GPR37 (Score: 0.566)

MODEL SYSTEM

mus_musculus

ESTIMATED COST

TIMELINE

0 months

PATHWAY

prosaposin-GPR37-IL-6 axis

SOURCE

pmid_39913287

PRIMARY OUTCOME

GPR37 deficiency in oligodendrocytes prevented neurodegeneration in multiple PD models, reducing neuroinflammation, dopamine neuron degeneration, and behavioral deficits.

Scoring Dimensions

Related Hypotheses (2)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.749

Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution0.680

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