Phosphorylated mTOR levels in axonal spheroids correlated with AD severity in human postmortem brains.

Neuropathology Score: 0.500 Price: $0.50 Alzheimer's disease in_vivo Status: extracted

What This Experiment Tests

Neuropathology experiment designed to assess clinical efficacy targeting MTOR in in_vivo. Primary outcome: Phosphorylated mTOR levels in axonal spheroids correlated with AD severity in human postmortem brain

Description

correlation analysis of phosphorylated mTOR with neuropathological AD severity metrics

TARGET GENE

MTOR (Score: 0.419)

MODEL SYSTEM

in_vivo

ESTIMATED COST

TIMELINE

0 months

PATHWAY

PI3K/AKT/mTOR

SOURCE

pmid_40065072

PRIMARY OUTCOME

Phosphorylated mTOR levels in axonal spheroids correlated with AD severity in human postmortem brains.

Scoring Dimensions

Related Hypotheses (4)

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease0.827

APOE-Dependent Autophagy Restoration0.877

Chronic mTORC1-ULK1 signaling blocks autophagy initiation in irradiated pericytes0.578

Metabolic Checkpoint Reprogramming via TREM2-mTOR Axis0.455

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