12 newly identified AD-associated genes show prior evidence linking them to neurofibrillary tangles or phosphorylated tau, with differential transcriptomic or proteomic expression between AD and healt

Computational Score: 0.500 Price: $0.50 Alzheimer's disease in_vitro Status: extracted

What This Experiment Tests

Computational experiment designed to assess clinical efficacy targeting PCDH9, NRG3, ROR1, LINGO2, SMYD3, LRRC7 in in_vitro. Primary outcome: 12 newly identified AD-associated genes show prior evidence linking them to neurofibrillary tangles

Description

Post hoc analysis of previously published differential expression data in AD brain tissue

TARGET GENE

PCDH9, NRG3, ROR1, LINGO2, SMYD3, LRRC7

MODEL SYSTEM

in_vitro

ESTIMATED COST

TIMELINE

0 months

PATHWAY

neurofibrillary tangle formation, tau phosphorylation

SOURCE

pmid_39775791

PRIMARY OUTCOME

12 newly identified AD-associated genes show prior evidence linking them to neurofibrillary tangles or phosphorylated tau, with differential transcriptomic or proteomic expression between AD and healthy brains for 10 of these genes.

Scoring Dimensions

Related Hypotheses (1)

Tau-trafficking GWAS loci define a druggable PTK2B endocytosis-kinase axis in AD0.600

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