Exploratory experiment designed to discover new patterns targeting ATE1, Tug (Aspscr1) in Cell culture. Primary outcome: TUG product protein stability
Investigation of how ATE1 arginyltransferase, an enzyme that mediates protein degradation and controls thermogenesis, regulates the stability of the TUG C-terminal cleavage product. This study revealed an additional layer of regulation in the TUG pathway through post-translational modification and protein degradation mechanisms.
Protein stability assays, pulse-chase experiments, proteasome inhibitor studies
ATE1 regulates degradation and stability of TUG C-terminal product
Demonstration of ATE1-dependent changes in TUG product levels
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