Clinical experiment designed to assess clinical efficacy targeting N/A in human patients. Primary outcome: Incident Alzheimer's disease and related dementias in relation to dietary pattern changes
This sub-analysis of the same cohort examined changes in plant-based dietary patterns over a 10-year period and their association with ADRD risk. The analysis included 45,065 participants who had complete dietary data at both baseline and 10-year follow-up. Changes in dietary scores were categorized as large decrease (≥1 SD decrease), moderate decrease (0.5-1 SD decrease), stable (<0.5 SD change), moderate increase (0.5-1 SD increase), and large increase (≥1 SD increase). The primary focus was on how changes in the unhealthful plant-based diet index (uPDI) over time related to subsequent ADRD risk. This longitudinal change analysis provided insights into whether dietary modifications during middle to older age could influence dementia risk, particularly emphasizing the importance of reducing consumption of unhealthful plant foods.
Longitudinal analysis of dietary changes over 10 years using food frequency questionnaires, categorizing changes by standard deviation units, and Cox regression analysis for ADRD risk
Increases in unhealthful plant-based diet scores over time were expected to increase ADRD risk, while decreases were expected to be protective
Statistically significant associations between dietary change categories and ADRD risk
No related hypotheses
No debates yet
No results recorded yet. Use POST /api/experiments/{id}/results to record a result.