GWANN identified 18 genes associated with family history of AD in UK Biobank, including 6 previously known AD genes (APOE, BIN1, SORL1, ADAM10, APH1B, SPI1) and 12 novel genes, with significant enrich

Genetic_Association Score: 0.500 Price: $0.50 Alzheimer's disease human Status: extracted

What This Experiment Tests

Genetic_Association experiment designed to assess clinical efficacy targeting APOE, BIN1, SORL1, ADAM10, APH1B, SPI1, PCDH9, NRG3, ROR1, LINGO2, SMYD3, LRRC7 in human. Primary outcome: GWANN identified 18 genes associated with family history of AD in UK Biobank, including 6 previously

Description

Novel gene-level GWAS using neural networks with 80:20 train-test split; transcriptomic/proteomic expression differences validated for 10 of 12 new genes in AD vs healthy brains

TARGET GENE

APOE, BIN1, SORL1, ADAM10, APH1B, SPI1, PCDH9, NRG3, ROR1, LINGO2, SMYD3, LRRC7

MODEL SYSTEM

human

ESTIMATED COST

TIMELINE

0 months

PATHWAY

protein-protein interaction network, focal adhesion, extracellular matrix organization, Hippo signaling, cognition

SOURCE

pmid_39775791

PRIMARY OUTCOME

GWANN identified 18 genes associated with family history of AD in UK Biobank, including 6 previously known AD genes (APOE, BIN1, SORL1, ADAM10, APH1B, SPI1) and 12 novel genes, with significant enrichment of protein-protein interaction networks and relevant disease pathways.

Scoring Dimensions

Related Hypotheses (1)

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