Exploratory experiment designed to discover new patterns targeting N/A in 1-month-old APP/PS1 mice and wild-type controls. Primary outcome: cerebral microvascular density and average vessel length
Immunofluorescence staining for CD31 was performed on cerebral cortical sections from 1-month-old APP/PS1 and wild-type mice to assess cerebral microvascular density and vessel morphology. This histological analysis aimed to characterize early microvascular changes in a mouse model of Alzheimer's disease by quantifying vessel density and average vessel length in the cerebral cortex.
Immunofluorescence staining for CD31 on cerebral cortical sections with quantitative analysis of vessel parameters
Reduced microvascular density in early-stage AD mice
Significant differences in microvascular density and vessel length between APP/PS1 and WT mice
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