Temporal analysis of cell-type proportions revealed early reduction of Somatostatin-expressing neuronal subtypes and late decrease of supragranular intratelencephalic-projecting excitatory and Parvalb

Cell_Biology Score: 0.500 Price: $0.50 Alzheimer's disease human Status: extracted

What This Experiment Tests

Cell_Biology experiment designed to assess clinical efficacy targeting SST|PVALB in human. Primary outcome: Temporal analysis of cell-type proportions revealed early reduction of Somatostatin-expressing neuro

Description

Cell proportion analysis across disease pseudoprogression timeline; disease-associated states identified by single cell profiling

TARGET GENE

SST|PVALB

MODEL SYSTEM

human

ESTIMATED COST

TIMELINE

0 months

PATHWAY

N/A

SOURCE

pmid_37292694

PRIMARY OUTCOME

Temporal analysis of cell-type proportions revealed early reduction of Somatostatin-expressing neuronal subtypes and late decrease of supragranular intratelencephalic-projecting excitatory and Parvalbumin-expressing neurons, with increases in disease-associated microglial and astrocytic states.

Scoring Dimensions

Related Hypotheses (1)

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease0.827

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