Resting-state functional connectivity analysis in ADAD carriers showed increased connectivity associated with tau deposition in limbic, posterior cortical and bilateral temporal regions overlapping wi

Neuropathology Score: 0.500 Price: $0.50 Alzheimer's disease in_vivo Status: extracted

What This Experiment Tests

Neuropathology experiment designed to assess clinical efficacy targeting null in in_vivo. Primary outcome: Resting-state functional connectivity analysis in ADAD carriers showed increased connectivity associ

Description

Resting-state functional connectivity (rsFC) mapping; Group 2 (higher tau) showed connectivity changes compared to Group 1 (lower tau)

TARGET GENE

null

MODEL SYSTEM

in_vivo

ESTIMATED COST

TIMELINE

0 months

PATHWAY

functional connectivity network

SOURCE

pmid_39962560

PRIMARY OUTCOME

Resting-state functional connectivity analysis in ADAD carriers showed increased connectivity associated with tau deposition in limbic, posterior cortical and bilateral temporal regions overlapping with the default mode network, along with reduced connectivity in left medial inferior temporal cortex and fusiform gyrus.

Scoring Dimensions

Related Hypotheses (1)

Hippocampus ages transcriptionally faster than cerebellum, defining a regional vulnerability axis co0.516

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