GPR37 was found to be upregulated in oligodendrocytes of the substantia nigra in parkinsonian mice, and prosaposin (PSAP) secretion was increased in these models.

Neuropathology Score: 0.500 Price: $0.50 Parkinson's disease animal_model Status: extracted

What This Experiment Tests

Neuropathology experiment designed to assess clinical efficacy targeting GPR37 in animal_model. Primary outcome: GPR37 was found to be upregulated in oligodendrocytes of the substantia nigra in parkinsonian mice,

Description

Examination of oligodendrocyte gene expression changes in substantia nigra of parkinsonian mouse models

TARGET GENE

GPR37 (Score: 0.566)

MODEL SYSTEM

animal_model

ESTIMATED COST

TIMELINE

0 months

PATHWAY

prosaposin-GPR37-IL-6 axis

SOURCE

pmid_39913287

PRIMARY OUTCOME

GPR37 was found to be upregulated in oligodendrocytes of the substantia nigra in parkinsonian mice, and prosaposin (PSAP) secretion was increased in these models.

Scoring Dimensions

Related Hypotheses (2)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.749

Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution0.680

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