Generated a knock-in Cre mouse line for Anxa1+ dopaminergic neurons to enable targeted manipulation of this population.

Genetic_Association Score: 0.500 Price: $0.50 Parkinson's disease mouse Status: extracted

What This Experiment Tests

Genetic_Association experiment designed to assess clinical efficacy targeting ANXA1 in mouse. Primary outcome: Generated a knock-in Cre mouse line for Anxa1+ dopaminergic neurons to enable targeted manipulation

Description

Genetic tool development - knock-in Cre line specifically targeting Anxa1+ neurons

TARGET GENE

ANXA1 (Score: 0.556)

MODEL SYSTEM

mouse

ESTIMATED COST

TIMELINE

0 months

PATHWAY

N/A

SOURCE

pmid_39763754

PRIMARY OUTCOME

Generated a knock-in Cre mouse line for Anxa1+ dopaminergic neurons to enable targeted manipulation of this population.

Scoring Dimensions

Related Hypotheses (2)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.749

Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics0.625

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