Proximity labeling proteomics of axonal spheroids in human postmortem AD brains identified abnormalities in protein turnover, cytoskeleton dynamics, and lipid transport with PI3K/AKT/mTOR pathway acti

Computational Score: 0.500 Price: $0.50 Alzheimer's disease in_vivo Status: extracted

What This Experiment Tests

Computational experiment designed to assess clinical efficacy targeting N/A in in_vivo. Primary outcome: Proximity labeling proteomics of axonal spheroids in human postmortem AD brains identified abnormali

Description

proximity labeling approach for subcellular proteomics of spheroids in postmortem brain tissue

TARGET GENE

N/A

MODEL SYSTEM

in_vivo

ESTIMATED COST

TIMELINE

0 months

PATHWAY

PI3K/AKT/mTOR pathway

SOURCE

pmid_40065072

PRIMARY OUTCOME

Proximity labeling proteomics of axonal spheroids in human postmortem AD brains identified abnormalities in protein turnover, cytoskeleton dynamics, and lipid transport with PI3K/AKT/mTOR pathway activation.

Scoring Dimensions

Related Hypotheses (1)

APOE4-Specific Proteolytic Fragment Inhibition Therapy0.777

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