Validation experiment designed to validate causal mechanisms targeting ACAT1 in unilateral ureteral obstruction mice. Primary outcome: reduction in renal fibrosis and mitochondrial injury
A second mouse model using unilateral ureteral obstruction (UUO) was employed to validate the renoprotective effects of hyperoside. This model provides an alternative approach to study kidney fibrosis progression and the therapeutic potential of hyperoside. Similar to the folic acid model, assessments included mitochondrial function, lipid metabolic remodeling, and fibrotic progression using multiple analytical approaches including histology, biochemistry, and ultrastructural examination.
surgical unilateral ureteral obstruction, hyperoside treatment, histological evaluation, biochemical analyses, electron microscopy
consistent renoprotective effects of hyperoside across different CKD models
reproducible reduction in fibrotic progression and mitochondrial dysfunction
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