Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in AD brain, with recurrent mutations in clonal hematopoiesis genes and up to 40% o

Genetic_Association Score: 0.500 Price: $0.50 Alzheimer's disease in_vivo Status: extracted

What This Experiment Tests

Genetic_Association experiment designed to assess clinical efficacy targeting cancer driver genes; CSF1R; clonal hematopoiesis genes in in_vivo. Primary outcome: Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in can

Description

Molecular-barcoded deep sequencing (>1000X coverage); analysis of sSNVs and sIndels in cancer driver genes

TARGET GENE

cancer driver genes; CSF1R; clonal hematopoiesis genes

MODEL SYSTEM

in_vivo

ESTIMATED COST

TIMELINE

0 months

PATHWAY

clonal hematopoiesis; microglial clonal expansion (MiCE)

SOURCE

pmid_38260600

PRIMARY OUTCOME

Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in AD brain, with recurrent mutations in clonal hematopoiesis genes and up to 40% of microglia carrying pathogenic sSNVs.

Scoring Dimensions

Related Hypotheses (1)

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease0.827

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