Validation experiment designed to validate causal mechanisms targeting N/A in mice. Primary outcome: bEV transport across blood-brain barrier
This experiment utilized in vivo imaging techniques and immunofluorescence to track and confirm the transport of blood-circulating LPS-carrying bacterial extracellular vesicles across the blood-brain barrier. The study aimed to demonstrate that these gut microbiota-derived vesicles could penetrate the brain's protective barrier, providing a mechanism for how peripheral LPS could reach brain tissue and potentially contribute to neuroinflammation in Alzheimer's disease.
In vivo imaging and immunofluorescence to track blood LPS-carrying bEVs crossing the BBB
Confirmation that LPS-carrying bEVs can traverse the BBB and enter brain tissue
Visualization of bEVs in brain tissue following blood administration
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