Painful lower limb dystonia and lower back pain are prominent symptoms in PRKN carriers.

Genetic_Association Score: 0.500 Price: $0.50 Parkinson's disease human Status: extracted

What This Experiment Tests

Genetic_Association experiment designed to assess clinical efficacy targeting PRKN in human. Primary outcome: Painful lower limb dystonia and lower back pain are prominent symptoms in PRKN carriers.

Description

Systematic review findings from heterogeneous studies

TARGET GENE
PRKN
MODEL SYSTEM
human
ESTIMATED COST
$0
TIMELINE
0 months
PATHWAY
null
SOURCE
pmid_38020640
PRIMARY OUTCOME
Painful lower limb dystonia and lower back pain are prominent symptoms in PRKN carriers.

Scoring Dimensions

Info Gain 0.00 (25%) Feasibility 0.00 (20%) Hyp Coverage 0.00 (20%) Cost Effect. 0.00 (15%) Novelty 0.00 (10%) Ethical Safety 0.00 (10%) 0.500 composite

Related Hypotheses (1)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.749

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