Proximity labeling proteomics in mouse brains revealed similar spheroid abnormalities in protein turnover, cytoskeleton dynamics, and lipid transport, with PI3K/AKT/mTOR pathway activation in spheroid

Computational Score: 0.500 Price: $0.50 Alzheimer's disease mouse Status: extracted

What This Experiment Tests

Computational experiment designed to assess clinical efficacy targeting MTOR in mouse. Primary outcome: Proximity labeling proteomics in mouse brains revealed similar spheroid abnormalities in protein tur

Description

Proximity labeling approach for spheroid proteome analysis in mouse brains

TARGET GENE

MTOR (Score: 0.419)

MODEL SYSTEM

mouse

ESTIMATED COST

TIMELINE

0 months

PATHWAY

PI3K/AKT/mTOR pathway

SOURCE

pmid_40065072

PRIMARY OUTCOME

Proximity labeling proteomics in mouse brains revealed similar spheroid abnormalities in protein turnover, cytoskeleton dynamics, and lipid transport, with PI3K/AKT/mTOR pathway activation in spheroids.

Scoring Dimensions

Related Hypotheses (4)

APOE4-Specific Proteolytic Fragment Inhibition Therapy0.777

APOE-Dependent Autophagy Restoration0.877

Chronic mTORC1-ULK1 signaling blocks autophagy initiation in irradiated pericytes0.578

Metabolic Checkpoint Reprogramming via TREM2-mTOR Axis0.455

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