Single nuclei multiomic profiling (transcriptomes, epigenomes, spatial coordinates) of 84 human donors spanning AD pathology spectrum mapped to a common cell type reference. Analysis revealed early re

Cell_Biology Score: 0.500 Price: $0.50 Alzheimer's disease human Status: extracted

What This Experiment Tests

Cell_Biology experiment designed to assess clinical efficacy targeting N/A in human. Primary outcome: Single nuclei multiomic profiling (transcriptomes, epigenomes, spatial coordinates) of 84 human dono

Description

Image-based quantitative neuropathology used to create continuous disease pseudoprogression score; single nuclei multiomic profiling with transcriptome and epigenome measurement; spatial transcriptomics; BRAIN Initiative Cell Census Network methodology; publicly available resource at SEA-AD.org

TARGET GENE

N/A

MODEL SYSTEM

human

ESTIMATED COST

TIMELINE

0 months

PATHWAY

N/A

SOURCE

pmid_37292694

PRIMARY OUTCOME

Single nuclei multiomic profiling (transcriptomes, epigenomes, spatial coordinates) of 84 human donors spanning AD pathology spectrum mapped to a common cell type reference. Analysis revealed early reduction of Somatostatin-expressing neuronal subtypes and late decreases in supragranular intratelencephalic-projecting excitatory and Parvalbumin-expressing neurons, with increases in disease-associated microglial and astrocytic states.

Scoring Dimensions

Related Hypotheses (1)

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease0.827

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