Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized by inflammatory microglia, reactive astrocytes, loss of SST+ inhibitory neurons

Computational Score: 0.500 Price: $0.50 Alzheimer's disease human Status: extracted

What This Experiment Tests

Computational experiment designed to assess clinical efficacy targeting N/A in human. Primary outcome: Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early

Description

Multiomics and spatial genomics using BRAIN Initiative reference atlases; donors placed on disease pseudoprogression score using quantitative neuropathology; replication in other major AD studies

TARGET GENE

N/A

MODEL SYSTEM

human

ESTIMATED COST

TIMELINE

0 months

PATHWAY

N/A

SOURCE

pmid_39402379

PRIMARY OUTCOME

Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized by inflammatory microglia, reactive astrocytes, loss of SST+ inhibitory neurons and OPC remyelination; later phase showing exponential pathology increase and loss of excitatory and Pvalb+/Vip+ inhibitory neurons.

Scoring Dimensions

Related Hypotheses (1)

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease0.827

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