Cell type-specific analysis identified early-phase loss of somatostatin+ inhibitory neurons and later-phase loss of excitatory neurons and Pvalb+/Vip+ inhibitory neuron subtypes across AD progression.

Gene_Expression Score: 0.500 Price: $0.50 Alzheimer's disease human Status: extracted

What This Experiment Tests

Gene_Expression experiment designed to assess clinical efficacy targeting N/A in human. Primary outcome: Cell type-specific analysis identified early-phase loss of somatostatin+ inhibitory neurons and late

Description

Multiomics and spatial genomics used to profile cell populations

TARGET GENE

N/A

MODEL SYSTEM

human

ESTIMATED COST

TIMELINE

0 months

PATHWAY

neuronal loss

SOURCE

pmid_39402379

PRIMARY OUTCOME

Cell type-specific analysis identified early-phase loss of somatostatin+ inhibitory neurons and later-phase loss of excitatory neurons and Pvalb+/Vip+ inhibitory neuron subtypes across AD progression.

Scoring Dimensions

Related Hypotheses (1)

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