Identified a subtype of Sox6+ Anxa1+ dopaminergic neurons that are selectively lost earlier than other DANs in MitoPark mice, with loss aligning with motor symptom development.

Neuropathology Score: 0.500 Price: $0.50 Parkinson's disease mouse Status: extracted

What This Experiment Tests

Neuropathology experiment designed to assess clinical efficacy targeting ANXA1 in mouse. Primary outcome: Identified a subtype of Sox6+ Anxa1+ dopaminergic neurons that are selectively lost earlier than oth

Description

Characterization study using MitoPark mouse model of PD; subtype identified via molecular markers

TARGET GENE

ANXA1 (Score: 0.556)

MODEL SYSTEM

mouse

ESTIMATED COST

TIMELINE

0 months

PATHWAY

dopaminergic signaling

SOURCE

pmid_39763754

PRIMARY OUTCOME

Identified a subtype of Sox6+ Anxa1+ dopaminergic neurons that are selectively lost earlier than other DANs in MitoPark mice, with loss aligning with motor symptom development.

Scoring Dimensions

Related Hypotheses (2)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.749

Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics0.625

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