Theta-Gamma Coupling Restoration Through PV Interneuron Optogenetic Modulation

In-Vivo Score: 0.850 Price: $0.50 Alzheimer disease Mouse (5xFAD or kcng1-tau model) with chronic implanted electrodes/optrodes Status: proposed

What This Experiment Tests

In-Vivo experiment designed to assess clinical efficacy targeting N/A in Mouse (5xFAD or kcng1-tau model) with chronic implanted electrodes/optrodes. Primary outcome: LFP theta-gamma coupling and spatial memory performance (MWM)

Description

Determine whether closed-loop optogenetic PV interneuron stimulation can restore theta-gamma coupling and improve spatial memory in a mouse model of AD or epilepsy with documented coupling deficits.

TARGET GENE

N/A

MODEL SYSTEM

Mouse (5xFAD or kcng1-tau model) with chronic implanted electrodes/optrodes

ESTIMATED COST

$50,000

TIMELINE

12 months

PATHWAY

N/A

SOURCE

auto-generated

PRIMARY OUTCOME

LFP theta-gamma coupling and spatial memory performance (MWM)

Scoring Dimensions

Protocol

in-vivo

Expected Outcomes

Closed-loop stimulation restores theta-gamma coupling (phase-amplitude coupling index restored to >80% of baseline) and improves spatial memory performance (Morris water maze) vs. open-loop or no-stimulation controls.

Success Criteria

LFP theta-gamma PAC (phase-amplitude coupling) and Morris water maze latency; threshold: p < 0.05 for both.

Related Hypotheses (0)

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