Inhibition of transmitter release specifically in Anxa1+ neurons was sufficient to induce bradykinesia and tremor, demonstrating this vulnerable subtype drives early motor symptoms.

Animal_Model Score: 0.500 Price: $0.50 Parkinson's disease mouse Status: extracted

What This Experiment Tests

Animal_Model experiment designed to assess clinical efficacy targeting ANXA1 in mouse. Primary outcome: Inhibition of transmitter release specifically in Anxa1+ neurons was sufficient to induce bradykines

Description

Functional experiment using genetic/inhibition approach; demonstrates sufficiency of Anxa1+ DANs for motor symptoms

TARGET GENE

ANXA1 (Score: 0.556)

MODEL SYSTEM

mouse

ESTIMATED COST

TIMELINE

0 months

PATHWAY

dopaminergic signaling

SOURCE

pmid_39763754

PRIMARY OUTCOME

Inhibition of transmitter release specifically in Anxa1+ neurons was sufficient to induce bradykinesia and tremor, demonstrating this vulnerable subtype drives early motor symptoms.

Scoring Dimensions

Related Hypotheses (2)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.749

Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics0.625

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