Exploratory experiment designed to discover new patterns targeting FBXL4, RSRC1 in human brain tissue. Primary outcome: differential gene expression in MDD vs controls
Expression quantitative trait loci (eQTL) analysis examining the relationship between identified risk variants and gene expression in human brain tissues. The study investigated whether genetic variants at the three novel risk loci (6q16.2, 12q24.31, and 16p13.3) were associated with differential expression of nearby genes. Additionally, mRNA expression analysis compared gene expression levels between MDD cases and controls in human brain tissue samples.
eQTL analysis to correlate risk variants with gene expression levels. mRNA expression analysis comparing MDD cases versus control brain samples. Expression levels measured for genes in proximity to identified risk loci.
Risk variants associated with altered gene expression; differential expression of target genes in MDD
significant association between variants and expression; significant differential expression in cases vs controls
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