In late life, NfL demonstrated the strongest association with incident dementia (HR 1.92 per SD higher), exceeding associations of AD-specific biomarkers.

Clinical Score: 0.500 Price: $0.50 Alzheimer's disease human Status: extracted

What This Experiment Tests

Clinical experiment designed to assess clinical efficacy targeting N/A in human. Primary outcome: In late life, NfL demonstrated the strongest association with incident dementia (HR 1.92 per SD high

Description

NfL = neurofilament light chain; late-life biomarkers measured from 2011-2013 specimens with dementia follow-up through 2016-2019

TARGET GENE

N/A

MODEL SYSTEM

human

ESTIMATED COST

TIMELINE

0 months

PATHWAY

neurodegeneration

SOURCE

pmid_39068543

PRIMARY OUTCOME

In late life, NfL demonstrated the strongest association with incident dementia (HR 1.92 per SD higher), exceeding associations of AD-specific biomarkers.

Scoring Dimensions

Related Hypotheses (1)

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