Released prosaposin (PSAP) was shown to induce interleukin-6 (IL-6) upregulation and secretion from oligodendrocytes via a GPR37-dependent pathway.

Cell_Biology Score: 0.500 Price: $0.50 Parkinson's disease cell_culture Status: extracted

What This Experiment Tests

Cell_Biology experiment designed to assess clinical efficacy targeting IL-6 in cell_culture. Primary outcome: Released prosaposin (PSAP) was shown to induce interleukin-6 (IL-6) upregulation and secretion from

Description

Cell culture experiments demonstrating PSAP-GPR37 signaling cascade leading to IL-6 production

TARGET GENE

IL-6

MODEL SYSTEM

cell_culture

ESTIMATED COST

TIMELINE

0 months

PATHWAY

prosaposin-GPR37-IL-6 axis

SOURCE

pmid_39913287

PRIMARY OUTCOME

Released prosaposin (PSAP) was shown to induce interleukin-6 (IL-6) upregulation and secretion from oligodendrocytes via a GPR37-dependent pathway.

Scoring Dimensions

Related Hypotheses (1)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.749

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