Identification of a vulnerable subtype of dopaminergic neurons co-expressing Sox6 and Anxa1 that shows selective vulnerability in PD.

Genetic_Association Score: 0.500 Price: $0.50 Parkinson's disease mouse Status: extracted

What This Experiment Tests

Genetic_Association experiment designed to assess clinical efficacy targeting Sox6, Anxa1 in mouse. Primary outcome: Identification of a vulnerable subtype of dopaminergic neurons co-expressing Sox6 and Anxa1 that sho

Description

Knock-in Cre mouse line generated for Anxa1+ DANs; differential anatomical inputs and outputs characterized

TARGET GENE

Sox6, Anxa1

MODEL SYSTEM

mouse

ESTIMATED COST

TIMELINE

0 months

PATHWAY

N/A

SOURCE

pmid_39763754

PRIMARY OUTCOME

Identification of a vulnerable subtype of dopaminergic neurons co-expressing Sox6 and Anxa1 that shows selective vulnerability in PD.

Scoring Dimensions

Related Hypotheses (1)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.749

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