Single nuclei transcriptomic and epigenomic profiling of 84 donors across AD pathology spectrum mapped to a common cell type reference, revealing complex gene expression differences from global to cel

Gene_Expression Score: 0.500 Price: $0.50 Alzheimer's disease human Status: extracted

What This Experiment Tests

Gene_Expression experiment designed to assess clinical efficacy targeting N/A in human. Primary outcome: Single nuclei transcriptomic and epigenomic profiling of 84 donors across AD pathology spectrum mapp

Description

Multiomic single nuclei sequencing (transcriptomes, epigenomes) combined with spatial coordinates; donors placed along continuous disease pseudoprogression score using image-based quantitative neuropathology

TARGET GENE

N/A

MODEL SYSTEM

human

ESTIMATED COST

TIMELINE

0 months

PATHWAY

N/A

SOURCE

pmid_37292694

PRIMARY OUTCOME

Single nuclei transcriptomic and epigenomic profiling of 84 donors across AD pathology spectrum mapped to a common cell type reference, revealing complex gene expression differences from global to cell type-specific effects with diverse temporal patterns.

Scoring Dimensions

Related Hypotheses (1)

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease0.827

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