In-Vivo experiment designed to assess clinical efficacy targeting N/A in C57BL/6 mice with vagotomy + enteric PFF injection. Primary outcome: p-Syn (Ser129) IHC burden in DMV and motor behavioral scores
Test whether unilateral vagus nerve transection blocks retrograde propagation of enterically-administered alpha-synuclein preformed fibrils (PFFs) to the ipsilateral brainstem, reducing PD-like motor deficits and Lewy body formation.
in-vivo
Vagotomized mice show >50% reduction in p-Syn (Ser129) pathology in the ipsilateral DMV and demonstrate attenuated motor impairment vs. sham-operated controls.
p-Syn pathology scoring in DMV (IHC); motor behavioral testing (rotarod, gait analysis); threshold: p < 0.05 for both.
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