Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated with clonal hematopoiesis; microglia carrying mCA exhibited upregulated pro-inf

Gene_Expression Score: 0.500 Price: $0.50 Alzheimer's disease in_vivo Status: extracted

What This Experiment Tests

Gene_Expression experiment designed to assess clinical efficacy targeting pro-inflammatory genes; DAM signature genes in in_vivo. Primary outcome: Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal al

Description

snRNAseq analysis of 62 additional AD cases and controls; mosaic chromosomal alteration (mCA) detection

TARGET GENE

pro-inflammatory genes; DAM signature genes

MODEL SYSTEM

in_vivo

ESTIMATED COST

TIMELINE

0 months

PATHWAY

neuroinflammation; disease-associated microglia (DAM) pathway

SOURCE

pmid_38260600

PRIMARY OUTCOME

Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated with clonal hematopoiesis; microglia carrying mCA exhibited upregulated pro-inflammatory genes resembling disease-associated microglia (DAM) signature.

Scoring Dimensions

Related Hypotheses (1)

APOE4-Specific Proteolytic Fragment Inhibition Therapy0.777

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